Hydrochloric Acid → HCID 4223896, 화합물

HRID 1085973노트

반응식

HRID 1085973 반응식
[C:1]([C:9]1[CH:14]=[CH:13][N:12]=[CH:11][CH:10]=1)(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:15]([NH:23][NH2:24])(=[O:22])[C:16]1[CH:21]=[CH:20][CH:19]=[N:18][CH:17]=1.Cl.C(=O)([O-])[O-].[Na+].[Na+]>O.C(O)C>[C:2]1([C:1](=[N:24][NH:23][C:15](=[O:22])[C:16]2[CH:21]=[CH:20][CH:19]=[N:18][CH:17]=2)[C:9]2[CH:14]=[CH:13][N:12]=[CH:11][CH:10]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 10340Sodium CarbonateHCID 11112Nicotinic acid, hydrazideHCID 267314-Benzoylpyridine

생성물 1

HCID 4223896HCID 4223896, 화합물수율 54.3%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

A mixture of 9.16 gm (0.05 mole) of 4-benzoyl pyridine, 6.86 gm (0.05 mole) of nicotinic acid hydrazide, 100 ml of ethanol and 4.4 ml of concentrated hydrochloric acid was refluxed 16 hr. The reaction mixture was cooled to room temperature. An equal volume of water was added containing 5.4 gm (0.05 mole) of sodium carbonate. The mixture was placed in the refrigerator. The product which separated was collected, washed with water and dried to give 8.21 gm (54%) of the title compound having a melting point of 74.0° C.

후처리

  1. temperaturewas refluxed 16 hr
  2. customThe product which separated
  3. customwas collected
  4. washwashed with water
  5. customdried

출처 및 근거

ORD 기록
ord-6a8347a257be475186da7756d5884bb9
출처 데이터셋
uspto-grants-1991_04
특허 번호
US05011932

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