1,3-Dibromo-5,5-dimethylhydantoin → 5-(Bromomethyl)quinoxaline

HRID 1086188

반응식

HRID 1086188 반응식
[CH3:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[N:4]=[CH:5][CH:6]=[N:7]2.[Br:12]N1C(C)(C)C(=O)N(Br)C1=O.C1(C(OO)=O)C=CC=CC=1>ClC(Cl)(Cl)Cl>[Br:12][CH2:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[N:4]=[CH:5][CH:6]=[N:7]2

참가 물질

5

반응물 3

HCID 64791,3-Dibromo-5,5-dimethylhydantoinHCID 616705-MethylquinoxalineHCID 523077Perbenzoic acid

생성물 1

HCID 101491295-(Bromomethyl)quinoxaline수율 100%

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

실험 절차

A mixture of 10 parts of 5-methylquinoxaline, 10 parts of 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione, 1.7 parts of benzenecarboperoxoic acid and 318 parts of tetrachloromethane was stirred for 16 hours at reflux temperature under 2 lamps of 250 Watt. The reaction mixture was cooled and the organic layer was decanted. The product was filtered off and dried, yielding 15.5 parts (100%) of 5-(bromomethyl)quinoxaline (interm. 1).

후처리

  1. temperatureat reflux temperature under 2 lamps of 250 Watt
  2. temperatureThe reaction mixture was cooled
  3. customthe organic layer was decanted
  4. filtrationThe product was filtered off
  5. customdried

출처 및 근거

ORD 기록
ord-920d3c4d604942e0800b3ae7e6412350
출처 데이터셋
uspto-grants-1991_07
특허 번호
US05028606

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