Hydrochloric Acid → 3-(4-Fluorophenyl)-3-methylbutan-2-one
반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](C)([CH3:11])[C:9]#N)=[CH:4][CH:3]=1.C[Li].Cl.C([O:18][CH2:19][CH3:20])C>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([CH3:11])([CH3:9])[C:19](=[O:18])[CH3:20])=[CH:4][CH:3]=1참가 물질
5
실험 절차
To a solution of 5.84 g 2-(4-fluorophenyl)-2-methylpropionitrile in abs. diethylether are added dropwise at -30° and under inert gas, 22 ml of a 1.6M solution of methyllithium in diethylether. The cooling bath is then taken away and the mixture stirred for 3 hours at room temperature. The reaction mixture is poured onto ice, the organic phase stirred overnight with 6N HCl, washed after separation of the acid phase, dried and evaporated in vacuum. The thus obtained oily residue is reacted further without purification.
후처리
- additionThe reaction mixture is poured onto ice
- washwashed
- customafter separation of the acid phase
- customdried
- customevaporated in vacuum
- customThe thus obtained oily residue is reacted further without purification
출처 및 근거
- ORD 기록
- ord-ceda18a4d2a54f94888e9665240f209d
- 출처 데이터셋
- uspto-grants-1991_07
- 특허 번호
- US05030625
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