Ammonia → 2-Undecyl-2-oxazoline

HRID 1086418

반응식

HRID 1086418 반응식
[CH2:1]([C:12]#[N:13])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11].N[CH2:15][CH2:16][OH:17].N>O.O.C([O-])(=O)C.[Cd+2].C([O-])(=O)C.C(O)CCC>[CH2:1]([C:12]1[O:17][CH2:16][CH2:15][N:13]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11]

참가 물질

6

반응물 3

HCID 222AmmoniaHCID 700EthanolamineHCID 17092Dodecanenitrile

생성물 1

HCID 3470762-Undecyl-2-oxazoline수율 88%

시약·촉매·용매 2

HCID 6537495Cadmium acetate, dihydrate촉매HCID 2631-Butanol용매

반응 조건

온도
125 °C

실험 절차

The reaction was carried out under nitrogen atmosphere in a three neck flask equipped with a magnetic stirring bar, reflux condenser, addition funnel and thermometer. 50 ml of 1-butanol and 667 mg (2.5 mmoles) of cadmium acetate dihydrate was introduced and the catalyst was dissolved by slight warming. 18.13 g (100 mmoles) of undecyl cyanide was added and the solution was heated to 125° C. 7.33 g (120 mmoles) of 2-aminoethanol was then added dropwise controlling the evolution of ammonia. At the end of the reaction (ca. 48 hrs.) the solvent was removed under vacuo. The residue was treated with 100 ml of petroleum ether and filtered after keeping for several hours. The filtrate was washed with water, dried over anhydrous magnesium sulfate, concentrated and the residue was distilled 114° C./0.5 mm to give 19.83 g (88%) of 2-undecyl-2-oxazoline.

후처리

  1. customequipped with a magnetic stirring bar
  2. temperaturereflux
  3. additioncondenser, addition funnel
  4. dissolutionthe catalyst was dissolved by slight warming
  5. customAt the end of the reaction (ca. 48 hrs.) the solvent
  6. customwas removed under vacuo
  7. additionThe residue was treated with 100 ml of petroleum ether
  8. filtrationfiltered
  9. waitafter keeping for several hours
  10. washThe filtrate was washed with water
  11. dry with materialdried over anhydrous magnesium sulfate
  12. concentrationconcentrated
  13. distillationthe residue was distilled 114° C./0.5 mm

출처 및 근거

ORD 기록
ord-fd788290069c4f7cb9cd5ed57b5a3c66
출처 데이터셋
uspto-grants-1991_07
특허 번호
US05030629

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