(2R,3S,4S,5R)-2,3,4,5,6-pentahydroxyhexanal → Lactulose

HRID 1086962

반응식

HRID 1086962 반응식
[CH2:1]([OH:23])[C@H:2]1[O:7][C@@H:6]([O:8][C@H:9]2[C@H:13]([OH:14])[C@@:12]([OH:17])([CH2:15][OH:16])[O:11][C@@H:10]2[CH2:18][OH:19])[C@H:5]([OH:20])[C@@H:4]([OH:21])[C@H:3]1[OH:22].O.O=C[C@@H]([C@H]([C@H]([C@@H](CO)O)O)O)O>>[CH2:1]([OH:23])[C@H:2]1[O:7][C@@H:6]([O:8][C@H:9]2[C@H:13]([OH:14])[C@@:12]([OH:17])([CH2:15][OH:16])[O:11][C@@H:10]2[CH2:18][OH:19])[C@H:5]([OH:20])[C@@H:4]([OH:21])[C@H:3]1[OH:22]

참가 물질

3

반응물 2

HCID 3037556(2R,3S,4S,5R)-2,3,4,5,6-pentahydroxyhexanalHCID 66964417(2S,3R,4S,5R,6R)-2-[(2R,3S,4S,5R)-4,5-dihydroxy-2,5-bis(hydroxymethyl)oxolan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol;hydrate2회

생성물 1

HCID 11333Lactulose수율 50.4%

실험 절차

A lactulose syrup was prepared in a manner similar to Example 1 except that the chromatography was practiced using XT-1007 (product of Tokyo Organic Chemical Industry Co., Ltd.) (crosslinking degree: 0.6%) as an ion-exchange resin. The peak of lactulose-containing fractions occurred about 123 minutes after the initiation of charging, while the peak of fractions containing monosaccharides such as galactose appeared about 167 minutes after the initiation of charging. The lactulose-containing fractions were collected and concentrated into a syrup, which had the following saccharide composition: 94.3 wt. % of lactulose and 4.2 wt. % of lactose, both based on the whole solids. The solid weight of lactulose was 201.5 kg, and its yield was 50.4% based on the starting lactose.

후처리

  1. waitappeared about 167 minutes
  2. customwere collected
  3. concentrationconcentrated into a syrup, which

출처 및 근거

ORD 기록
ord-d4d41a74b2f84f018596b0b82a748131
출처 데이터셋
uspto-grants-1991_07
특허 번호
US05034064

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