Acetic Anhydride → N-(3-Chlorophenyl)acetamide

반응식

[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][CH:8]=1)[NH2:5].[C:9](OC(=O)C)(=[O:11])[CH3:10]>>[C:9]([NH:5][C:4]1[CH:6]=[CH:7][CH:8]=[C:2]([Cl:1])[CH:3]=1)(=[O:11])[CH3:10]

참가 물질

반응물 2

HCID 7918Acetic Anhydride

HCID 79323-Chloroaniline

생성물 1

HCID 11493N-(3-Chlorophenyl)acetamide수율 226.8%

반응 조건

온도: 90 °C

실험 절차

To 3-chloroaniline (10 g, 0.078 mol) was added portionwise acetic anhydride (32 g, 0.314 mol) in such a manner as to keep the temperature of the reaction mixture below 85° C. The reaction mixture was then stirred at 90° C. for 4 hours and then cooled to room temperature. The reaction mixture was then poured carefully into ice water, extracted with ethyl acetate and dried over sodium sulfate. The solvent was removed, yielding 30 g of N-acetyl-3-chloroaniline.

후처리

customthe temperature of the reaction mixture below 85° C
temperaturecooled to room temperature
extractionextracted with ethyl acetate
dry with materialdried over sodium sulfate
customThe solvent was removed

출처 및 근거

ORD 기록: ord-c22f2be1bb7d4cd7a687f81dea07ae3a
출처 데이터셋: uspto-grants-1991_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05034410

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