Ethanol → Ethyl 3-(2,4-difluorophenylthio)-4-nitrobenzoate

HRID 1087174노트

반응식

HRID 1087174 반응식
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[S:9][C:10]1[CH:11]=[C:12]([CH:16]=[CH:17][C:18]=1[N+:19]([O-:21])=[O:20])[C:13]([OH:15])=[O:14].[CH2:22](O)[CH3:23]>Cl>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[S:9][C:10]1[CH:11]=[C:12]([CH:16]=[CH:17][C:18]=1[N+:19]([O-:21])=[O:20])[C:13]([O:15][CH2:22][CH3:23])=[O:14]

참가 물질

4

반응물 2

HCID 702EthanolHCID 100867683-(2,4-Difluorophenylthio)-4-nitrobenzoic acid

생성물 1

HCID 10359815Ethyl 3-(2,4-difluorophenylthio)-4-nitrobenzoate

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

A solution of 3-(2,4-difluorophenylthio)-4-nitrobenzoic acid (1.2 g) in 20% hydrogen chloride in ethanol (3 ml) was refluxed for 2 hours. The mixture was concentrated. The residue was dissolved in ethyl acetate and washed with an aqueous solution of sodium bicarbonate and water successively. The extract was evaporated and the residual oil was crystallized from a mixture of hexane and ethanol to give crystals of ethyl 3-(2,4-difluorophenylthio)-4-nitrobenzoate (1.1 g).

후처리

  1. concentrationThe mixture was concentrated
  2. dissolutionThe residue was dissolved in ethyl acetate
  3. washwashed with an aqueous solution of sodium bicarbonate and water successively
  4. customThe extract was evaporated
  5. customthe residual oil was crystallized from a mixture of hexane and ethanol

출처 및 근거

ORD 기록
ord-21550f48741d48fda2cb1c5a0abf243d
출처 데이터셋
uspto-grants-1991_07
특허 번호
US05034417

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