Hydrochloric Acid → HCID 22163789, 화합물

HRID 1087831

반응식

HRID 1087831 반응식
[CH3:1][N:2]([CH3:21])[CH2:3][CH2:4][NH:5][C:6](N1CCN(C2C=CC(F)=CC=2)CC1)=[O:7].C(N1C=CN=C1)(N1C=CN=C1)=O.CN(CCN)C.[CH3:40][O:41][C:42]1[CH:43]=[C:44]([N:50]2[CH2:55][CH2:54][NH:53][CH2:52][CH2:51]2)[CH:45]=[CH:46][C:47]=1[O:48][CH3:49].[ClH:56]>O1CCCC1>[ClH:56].[CH3:40][O:41][C:42]1[CH:43]=[C:44]([N:50]2[CH2:51][CH2:52][N:53]([C:6]([NH:5][CH2:4][CH2:3][N:2]([CH3:21])[CH3:1])=[O:7])[CH2:54][CH2:55]2)[CH:45]=[CH:46][C:47]=1[O:48][CH3:49]

참가 물질

7

반응물 5

HCID 313Hydrochloric AcidHCID 66053N,N-DimethylethylenediamineHCID 682631,1'-CarbonyldiimidazoleHCID 27362071-(3,4-Dimethoxyphenyl)piperazineHCID 14763463HCID 14763463, 화합물

생성물 1

HCID 22163789HCID 22163789, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

This compound was prepared according to the procedure used to synthesize the compound of Example 11. A mixture of 1.6 g (0.01 mole) of 1,1'-carbonyldiimidazole, 0.87 g (0.01 mole) of unsym-dimethylethylenediamine, and 2.2 g (0.01 mole) of 1-(3,4-dimethoxyphenyl)piperazine in a total volume of 50 ml of tetrahydrofuran gave an oil as residue. The hydrochloride was formed in ethereal hydrogen chloride and the collected solid was recrystallized twice from methanolethyl ether to yield 2.3 g (57%) of the title compound as an off-white solid, m.p. 208°-210° C.

후처리

  1. customThis compound was prepared
  2. customgave an oil as residue

출처 및 근거

ORD 기록
ord-00e881a7eb4e4ff894ad2763a577617e
출처 데이터셋
uspto-grants-1990_10
특허 번호
US04960776

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