Epichlorohydrin → 1-Benzenesulfonyl-4-(3-chloro-2-hydroxypropyl)piperazine

HRID 1087873

반응식

[CH2:1]([CH:3]1[O:5][CH2:4]1)[Cl:2].[C:6]1([S:12]([N:15]2[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)(=[O:14])=[O:13])[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>>[C:6]1([S:12]([N:15]2[CH2:20][CH2:19][N:18]([CH2:4][CH:3]([OH:5])[CH2:1][Cl:2])[CH2:17][CH2:16]2)(=[O:14])=[O:13])[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

참가 물질

반응물 2

HCID 7835Epichlorohydrin

HCID 8087121-(Benzenesulfonyl)piperazine

생성물 1

HCID 147198721-Benzenesulfonyl-4-(3-chloro-2-hydroxypropyl)piperazine수율 98.7%

실험 절차

Epichlorohydrin (0.5 g) and 3.7 g of 1-benzenesulfonylpiperazine were reacted and worked up in the same way as in Referential Example 1 to give 1.7 g of 1-benzenesulfonyl-4-(3-chloro-2-hydroxypropyl)piperazine as a colorless powdery crystal having a melting point of 136 to 137° C.

출처 및 근거

ORD 기록: ord-ba92a102c7c44ba78f34d2ae55fffc90
출처 데이터셋: uspto-grants-1990_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04960883

연결된 노트

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