Sodium Hydroxide → Minoxidil

HRID 1087883

반응식

HRID 1087883 반응식
C([NH:4][C:5]1[N:10]([O:11]C(=O)C)[C:9](=[NH:15])[N:8]=[C:7]([N:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)[CH:6]=1)(=O)C.[OH-].[Na+]>C(O)C>[NH2:4][C:5]1[N:10]([OH:11])[C:9](=[NH:15])[N:8]=[C:7]([N:16]2[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21]2)[CH:6]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 140353009HCID 140353009, 화합물

생성물 1

HCID 4201Minoxidil

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

1.0 g (3.4 mmoles) of 6-acetamido-1-acetoxy-1,2-dihydro-2-imino-4-piperidinopyrimidine prepared as described in Example 7 is dissolved in a mixture containing 20 ml of ethanol and 5 ml of 1N aqueous sodium hydroxide solution, the mixture is refluxed for 30 minutes, then evaporated under reduced pressure. Taking up the residue in 10 ml of water, the crystals are filtered, washed with water and dried to give the aimed compound in a yield of 0.54 g (76%), which shows no melting point depression when mixed with the product of Example 1.

후처리

  1. dissolutionis dissolved in a mixture
  2. temperaturethe mixture is refluxed for 30 minutes
  3. customevaporated under reduced pressure
  4. filtrationthe crystals are filtered
  5. washwashed with water
  6. customdried

출처 및 근거

ORD 기록
ord-bd0a4a8219f34b3488950ee14ff77a09
출처 데이터셋
uspto-grants-1990_10
특허 번호
US04960888

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