2-Hydroxy-1-naphthaldehyde → 2-(2-Fluoroethoxy)-1-hydroxymethylnaphthalene

HRID 1087901

반응식

HRID 1087901 반응식
[F:1][CH2:2][CH2:3][O:4][C:5]1[CH:14]=[CH:13][C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]=1[CH:15]=[O:16].OC1C=CC2C(=CC=CC=2)C=1C=O.[BH4-].[Na+]>C(O)C.O>[F:1][CH2:2][CH2:3][O:4][C:5]1[CH:14]=[CH:13][C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]=1[CH2:15][OH:16]

참가 물질

6

반응물 3

HCID 128192-Hydroxy-1-naphthaldehydeHCID 4311764Sodium borohydrideHCID 150587342-(2-Fluoroethoxy)-1-naphthaldehyde

생성물 1

HCID 150587332-(2-Fluoroethoxy)-1-hydroxymethylnaphthalene수율 45.4%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

A solution of 2.5 grams (0.012 mole) of 2-(2-fluoroethoxy)-1-naphthaldehyde (prepared by the method of Example 1 from 2-hydroxy-1-naphthaldehyde) and 0.6 gram (0.015 mole) of sodium borohydride in 35 ml of ethanol was stirred at room temperature for 24 hours. The mixture was diluted with water and extracted with diethyl ether. The extract was dried over anhydrous magnesium sulfate and filtered. The filtrate was evaporated under reduced pressure to yield 1.2 gram of 2-(2-fluoroethoxy)-1-hydroxymethylnaphthalene as a solid.

후처리

  1. extractionextracted with diethyl ether
  2. dry with materialThe extract was dried over anhydrous magnesium sulfate
  3. filtrationfiltered
  4. customThe filtrate was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-8c2fb2ca43f34f948047a93f82ef72e7
출처 데이터셋
uspto-grants-1990_10
특허 번호
US04960884

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