Potassium Carbonate → Isoflavone

HRID 1087967

반응식

HRID 1087967 반응식
SC1SCCN=1.O[C:8]1[CH:28]=[CH:27][C:11]([C:12]2[C:21](=[O:22])[C:20]3[C:15](=[CH:16][C:17](O)=[CH:18][C:19]=3O)[O:14][C:13]=2CBr)=[CH:10][CH:9]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[O:14]1[C:15]2[C:20](=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:21](=[O:22])[C:12]([C:11]2[CH:27]=[CH:28][CH:8]=[CH:9][CH:10]=2)=[CH:13]1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 15598731HCID 15598731, 화합물HCID 178527880HCID 178527880, 화합물

생성물 1

HCID 72304Isoflavone

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

2-Mercaptothiazoline (35 mg) was added to a mixture of 4',5,7-trihydroxy-2-bromomethylisoflavone (50 mg), anhydrous potassium carbonate (21 mg) and N,N-dimethylformamide (1 ml), and the resulting mixture was stirred at room temperature for 10 hours. The solvent was distilled off under reduced pressure, and the residue was purified by silica gel column chromatography (eluent:chloroform), giving 32 mg of 4',5,7-trihydroxy-2-[2-thiazolin-2-ylthio)methyl]isoflavone as amorphous powder.

후처리

  1. distillationThe solvent was distilled off under reduced pressure
  2. customthe residue was purified by silica gel column chromatography (eluent:chloroform)

출처 및 근거

ORD 기록
ord-99102570174b4c99a5b3387caa3efdc8
출처 데이터셋
uspto-grants-1990_10
특허 번호
US04960908

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