Hydrochloric Acid → (S)-2-CHLORO-4-METHYL-N-VALERIC ACID

HRID 1088194노트

반응식

HRID 1088194 반응식
N[C@H:2]([C:7]([OH:9])=[O:8])[CH2:3][CH:4]([CH3:6])[CH3:5].[ClH:10].NC(N)=O>[N+]([O-])(O)=O>[Cl:10][C@@H:2]([CH2:3][CH:4]([CH3:6])[CH3:5])[C:7]([OH:9])=[O:8]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 1176UreaHCID 6106L-Leucine

생성물 1

HCID 12732683(S)-2-CHLORO-4-METHYL-N-VALERIC ACID

시약·촉매·용매 1

HCID 944Nitric Acid용매

반응 조건

온도
80 °C

실험 절차

L-(+)-Leucine (10 g, 0.076 moles) is mixed with 24 mL of concentrated HCl and 10 mL of concentrated HNO3 with the addition of 2 g of urea and subsequently heated for 1 hour at 80° C. and then for 1 hour at 50° C. on a water bath (complete dissolution of the acid with heavy foaming). After cooling, the solution is extracted with ether several times, the ether extract is washed with water and dried over calcium chloride, the solvent is distilled off in a rotary evaporator and the residue is fractionally distilled under vacuum.

후처리

  1. dissolutionfor 1 hour at 50° C. on a water bath (complete dissolution of the acid with heavy foaming)
  2. temperatureAfter cooling
  3. extractionthe solution is extracted with ether several times
  4. extractionthe ether extract
  5. washis washed with water
  6. dry with materialdried over calcium chloride
  7. distillationthe solvent is distilled off in a rotary evaporator
  8. distillationthe residue is fractionally distilled under vacuum

출처 및 근거

ORD 기록
ord-2c00c676e0c1468a958b90074c5ddc6b
출처 데이터셋
uspto-grants-1990_10
특허 번호
US04961876

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