Potassium Carbonate → HCID 54541299, 화합물

HRID 1088448노트

반응식

HRID 1088448 반응식
C(=O)([O-])[O-].[K+].[K+].[OH:7][C:8]1[CH:9]=[C:10]([CH:14]=[CH:15][C:16]2[CH:25]=[CH:24][C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[N:17]=2)[CH:11]=[CH:12][CH:13]=1.[CH3:26][O:27][C:28](=[O:31])[CH2:29]Br>CC(C)=O>[N:17]1[C:18]2[C:23](=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:24]=[CH:25][C:16]=1[CH:15]=[CH:14][C:10]1[CH:9]=[C:8]([CH:13]=[CH:12][CH:11]=1)[O:7][CH2:29][C:28]([O:27][CH3:26])=[O:31]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 60984Methyl bromoacetateHCID 48788413-(2-Quinolin-2-yl-vinyl)-phenol

생성물 1

HCID 54541299HCID 54541299, 화합물

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A suspension of milled potassium carbonate (0.5 g), quinoline from Step 2 (1.1 g), and methylbromoacetate (4.0 ml) in acetone (25 ml) were refluxed overnight. The reaction mixture is poured onto water, extracted with ethyl acetate dried and evaporated. Chromatography of the residue on SiO2 using 30 to 40% ether/hexane afforded the title compound: m.p. 110-112°.

후처리

  1. temperaturewere refluxed overnight
  2. additionThe reaction mixture is poured onto water
  3. extractionextracted with ethyl acetate
  4. customdried
  5. customevaporated

출처 및 근거

ORD 기록
ord-b7a841ca62e44bfca5a60744eacba619
출처 데이터셋
uspto-grants-1990_10
특허 번호
US04962203

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