Sodium cyanoborohydride → 3-Chloro-4,5-dihydro-7-[3-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine
반응식
[Cl:1][C:2]1[CH:3]=[N:4][N:5]2[C:10]([C:11]3[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([F:20])([F:19])[F:18])[CH:12]=3)=[CH:9][CH:8]=[N:7][C:6]=12.C([BH3-])#N.[Na+]>C(O)(=O)C>[Cl:1][C:2]1[CH:3]=[N:4][N:5]2[C:10]([C:11]3[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([F:20])([F:19])[F:18])[CH:12]=3)=[CH:9][CH2:8][NH:7][C:6]=12참가 물질
4
실험 절차
A 13.3 g portion of 3-chloro-7-[3-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidine and 7 g of sodium cyanoborohydride in 150 ml of acetic acid, were reacted as described in Example 1, giving 6.7 g of 3-chloro-4,5-dihydro-7-[3-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine.
출처 및 근거
- ORD 기록
- ord-471cc16189784d8b923850361665cd48
- 출처 데이터셋
- uspto-grants-1990_10
- 특허 번호
- US04963553
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