Sodium Hydroxide → HCID 14685752, 화합물
반응식
O=C1[O:7][CH2:6][C:5]2[CH:8]=[CH:9][CH:10]=[C:11]3[CH:12]([N:15]([CH3:19])[CH2:16][CH:17]=[CH2:18])[CH2:13][CH2:14][N:3]1[C:4]=23.[OH-].[Na+]>CO>[CH3:19][N:15]([CH:12]1[C:11]2[C:4](=[C:5]([CH2:6][OH:7])[CH:8]=[CH:9][CH:10]=2)[NH:3][CH2:14][CH2:13]1)[CH2:16][CH:17]=[CH2:18]참가 물질
4
실험 절차
To a solution of 6,7-dihydro-3-oxo-7-(N-methyl-N-allylamino)-1H,3H,5H-pyrido[3,2,1-ij][3,1]benzoxazine (5.89 g) in methanol (80 ml) was added 15% aqueous solution of sodium hydroxide (20 ml) and the mixture was refluxed for 6 hours. After distilling off methanol and extracting with dichloromethane, the extract was dried over anhydrous magnesium sulfate. The solvent was distilled off to give 4-(N-methyl-N-allylamino)-8-hydroxymethyl-1,2,3,4-tetrahydroquinoline (4.83 g).
후처리
- temperaturethe mixture was refluxed for 6 hours
- distillationAfter distilling off methanol
- extractionextracting with dichloromethane
- dry with materialthe extract was dried over anhydrous magnesium sulfate
- distillationThe solvent was distilled off
출처 및 근거
- ORD 기록
- ord-326edb2efc114f51bd093489be4da1d0
- 출처 데이터셋
- uspto-grants-1990_10
- 특허 번호
- US04963566
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