Hydrochloric Acid → 4-(Aminomethyl)pyrrolidin-3-ol dihydrochloride

HRID 1089219노트

반응식

HRID 1089219 반응식
[OH:1][CH:2]1[CH:6]([CH2:7][NH2:8])[CH2:5][N:4](CC2C=CC=CC=2)[CH2:3]1.[ClH:16]>CO.C(O)C.[Pd]>[ClH:16].[ClH:16].[OH:1][CH:2]1[CH:6]([CH2:7][NH2:8])[CH2:5][NH:4][CH2:3]1

참가 물질

6

반응물 2

HCID 313Hydrochloric AcidHCID 139598933-Hydroxy-4-aminomethyl-1-phenylmethyl pyrrolidine

생성물 1

HCID 148395874-(Aminomethyl)pyrrolidin-3-ol dihydrochloride수율 70%

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 702Ethanol용매HCID 887Methanol용매

실험 절차

A solution of 2.9 g (10.6 mmol) of 3-hydroxy-4-aminomethyl-1-phenylmethyl pyrrolidine in 60 ml anhydrous methanol and 5.3 ml 5N hydrochloric acid in ethanol was hydrogenized over 1.83 g palladium on carbon for 17 hours. The catalyst was filtered off, the solvent removed to afford 1.39 g (70%) of title compound.

후처리

  1. filtrationThe catalyst was filtered off
  2. customthe solvent removed

출처 및 근거

ORD 기록
ord-b559d7a33a894657babbbff36d1cdec3
출처 데이터셋
uspto-grants-1990_10
특허 번호
US04965273

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