Methanol → Genipin

HRID 1089629노트

반응식

HRID 1089629 반응식
[CH3:1][O:2][C:3]([C:5]1[C@H:10]2[CH2:11][CH:12]=[C:13]([CH2:14][OH:15])[C@H:9]2[C@H:8]([O:16][C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[O:7][CH:6]=1)=[O:4].C(Cl)(Cl)Cl.CO.S(=O)(=O)(O)O>O>[CH3:1][O:2][C:3]([C:5]1[C@H:10]2[CH2:11][CH:12]=[C:13]([CH2:14][OH:15])[C@H:9]2[C@H:8]([OH:16])[O:7][CH:6]=1)=[O:4]

참가 물질

6

반응물 4

HCID 887MethanolHCID 1118Sulfuric AcidHCID 6212ChloroformHCID 107848Geniposide

생성물 1

HCID 442424Genipin수율 67.3%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a solution of geniposide (6.5 g) dissolved in distilled water (65 ml), was added β-glucosidase (No.G-0395, β-D-glucoside glucohydrase EC 3.2.1.21) (316.55 mg, 1677.72 units) the mixture was incubated at 37° C. for 4.5 hours. The progress of the reaction was monitored by TLC (chloroform:methanol=8:2, visualized with 50%-sulfuric acid). After the reaction was complete, the reaction solution was extracted several times with ethyl acetate, and subsequently the ethyl acetate layer was concentrated to give genipin as white needles (2.55 g, yield 67.3%).

후처리

  1. extractionthe reaction solution was extracted several times with ethyl acetate
  2. concentrationsubsequently the ethyl acetate layer was concentrated

출처 및 근거

ORD 기록
ord-dfa9eb9e0d0049099466fed33b18ae6f
출처 데이터셋
uspto-grants-1992_01
특허 번호
US05078750

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