Hydrochloric Acid → 3-Ethylisoxazole-5-carboxanilide

HRID 1090015노트

반응식

HRID 1090015 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:8]([C:10]1[CH:14]=[C:13]([C:15](Cl)=[O:16])[O:12][N:11]=1)[CH3:9].O.Cl>ClCCl>[CH2:8]([C:10]1[CH:14]=[C:13]([C:15]([NH:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[O:16])[O:12][N:11]=1)[CH3:9]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 6115AnilineHCID 129051013-Ethylisoxazole-5-carbonyl chloride

생성물 1

HCID 156929113-Ethylisoxazole-5-carboxanilide수율 87.1%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

11.7 g of aniline are added dropwise to 10.0 g of 3-ethylisoxazole-5-carbonyl chloride in 150 ml of dichloromethane, while cooling with ice. The mixture is stirred overnight at room temperature, water and concentrated hydrochloric acid are added and the organic phase is separated off, washed with sodium bicarbonate solution and evaporated down to give 11.8 g of 3-ethylisoxazole-5-carboxanilide as colorless crystals of melting point 122°-124° C.

후처리

  1. temperaturewhile cooling with ice
  2. customthe organic phase is separated off
  3. washwashed with sodium bicarbonate solution
  4. customevaporated down

출처 및 근거

ORD 기록
ord-803f5bed721f49bab3dbac2f5d8197d3
출처 데이터셋
uspto-grants-1992_01
특허 번호
US05080708

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