3-Pyridinemethanol → 2-(Pyridin-3-yloxy)acetonitrile
반응식
N1C=CC=C(C[O:8][CH2:9][CH2:10][NH2:11])C=1.[Na].[N:13]1[CH:18]=[CH:17][CH:16]=[C:15](CO)[CH:14]=1.ClCC#N>CN(C)C=O>[N:13]1[CH:18]=[CH:17][CH:16]=[C:15]([O:8][CH2:9][C:10]#[N:11])[CH:14]=1참가 물질
6
실험 절차
The starting amine, (3-pyridinyl)methyloxyethylamine, was prepared by the following procedure: reaction of the sodium salt of 3-pyridinylmethanol and chloracetonitrile in dimethylformamide gave 2-(3-pyridinyloxy)acetonitrile, which, upon reduction with borane in tetrahydroduran solution, gave the desired amine.
출처 및 근거
- ORD 기록
- ord-f651c32dc42d41d5956b9b9d5d8f681f
- 출처 데이터셋
- uspto-grants-1992_01
- 특허 번호
- US05081131
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