2-Methyl-3-nitrobenzyl alcohol → (3-Amino-2-methylphenyl)methanol

HRID 1090633

반응식

HRID 1090633 반응식
[CH3:1][C:2]1[C:9]([N+:10]([O-])=O)=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][OH:5]>C(O)C.[Pd]>[NH2:10][C:9]1[C:2]([CH3:1])=[C:3]([CH:6]=[CH:7][CH:8]=1)[CH2:4][OH:5]

참가 물질

4

반응물 1

HCID 902892-Methyl-3-nitrobenzyl alcohol

생성물 1

HCID 577175(3-Amino-2-methylphenyl)methanol수율 101.4%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A solution of 2-methyl-3-nitrobenzyl alcohol (2.0 g, 12 mmol) in ethanol (100 ml) was hydrogenated over 10% palladium/charcoal (0.1 g) for 2 hours, at an initial pressure of 3.5 bar. The solution was filtered through celite and evaporated to give 3-amino-2-methylbenzyl alcohol (1.67 g, quantitative), m.p. 104°-106°

후처리

  1. filtrationThe solution was filtered through celite
  2. customevaporated

출처 및 근거

ORD 기록
ord-964ca6295eb64af1ac47407e4136b9c0
출처 데이터셋
uspto-grants-1992_01
특허 번호
US05082848

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