Ethanol → 4-Tetradecylpyrrole-2-carboxylic acid

HRID 1090739노트

반응식

HRID 1090739 반응식
[OH-].[Na+].C(O)C.[CH2:6]([C:20]1[CH:21]=[C:22]([C:25]([O:27]C)=[O:26])[NH:23][CH:24]=1)[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19]>O>[CH2:6]([C:20]1[CH:21]=[C:22]([C:25]([OH:27])=[O:26])[NH:23][CH:24]=1)[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19]

참가 물질

5

반응물 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 19371041Methyl 4-tetradecylpyrrole-2-carboxylate

생성물 1

HCID 150232964-Tetradecylpyrrole-2-carboxylic acid수율 95%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution (1 ml) of 2N sodium hydroxide was added to an ethanol solution (5 ml) of 0.22 g (0.69 mmol) of methyl 4-tetradecylpyrrole-2-carboxylate prepared in Example 9 and heated under reflux for 13 hours. Water was added to the resulting mixture, and then washed with ether. After acidifying the aqueous layer with hydrochloric acid, the mixture was extracted with ether and dried over anhydrous magnesium sulfate. The removal of the solvent afforded 0.19 g (95% yield) of 4-tetradecylpyrrole-2-carboxylic acid, m.p. 148°-150° C.

후처리

  1. temperatureheated
  2. temperatureunder reflux for 13 hours
  3. washwashed with ether
  4. extractionthe mixture was extracted with ether
  5. dry with materialdried over anhydrous magnesium sulfate
  6. customThe removal of the solvent

출처 및 근거

ORD 기록
ord-857c7f8cb66d4795b612d56f31b2c8a7
출처 데이터셋
uspto-grants-1992_01
특허 번호
US05082856

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