Sodium Hydroxide → 4-(quinolin-2-ylmethoxy)benzoic Acid

HRID 1090793

반응식

HRID 1090793 반응식
C[O:2][C:3](=[O:22])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][C:12]2[CH:21]=[CH:20][C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[N:13]=2)=[CH:6][CH:5]=1.[OH-].[Na+]>C(O)C>[N:13]1[C:14]2[C:19](=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:20]=[CH:21][C:12]=1[CH2:11][O:10][C:7]1[CH:8]=[CH:9][C:4]([C:3]([OH:22])=[O:2])=[CH:5][CH:6]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 19934817Methyl 4-(2-quinolinylmethoxy)benzoate

생성물 1

HCID 98385524-(quinolin-2-ylmethoxy)benzoic Acid수율 65.5%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

5.00 g of methyl-4-(quinolin-2-ylmethoxy)benzoate is dissolved in 120 ml of ethanol and 90 ml of 1N sodium hydroxide and the mixture is stirred at room temperature for 4 days. The mixture is concentrated in vacuo to remove the ethanol. The residue is diluted with water, acidified to pH 6 and the resulting solid is filtered off and recrystallized from methanol to give 3.12 g 4-(quinolin-2-ylmethoxy)benzoic acid.

후처리

  1. concentrationThe mixture is concentrated in vacuo
  2. customto remove the ethanol
  3. additionThe residue is diluted with water
  4. filtrationthe resulting solid is filtered off
  5. customrecrystallized from methanol

출처 및 근거

ORD 기록
ord-813a8b5498a34ca9a99a75095311e39c
출처 데이터셋
uspto-grants-1992_01
특허 번호
US05082849

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