Sodium Hydroxide → 1-Phenyl-1H-pyrazole-5-carboxylic acid

HRID 1090809노트

반응식

HRID 1090809 반응식
[C:1]1([N:7]2[C:11]([C:12]([O:14]CC)=[O:13])=[CH:10][CH:9]=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+]>C(O)C>[C:1]1([N:7]2[C:11]([C:12]([OH:14])=[O:13])=[CH:10][CH:9]=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 6424675Ethyl 1-phenyl-1H-pyrazole-5-carboxylate

생성물 1

HCID 2370561-Phenyl-1H-pyrazole-5-carboxylic acid수율 81%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

4.4 g of ethyl 1-phenylpyrazole-5-carboxylate from Example 1 were stirred for 6 hours at room temperature with 10 ml of 16.5% strength aqueous NaOH and 10 ml of ethanol; the ethanol was removed by distillation, the aqueous phase was extracted twice with 10 ml of toluene, and the pH was adjusted to 3 using concentrated HCl. The precipitate was filtered off under suction, washed with a little water and dried: 3.1 g of product of boiling point 182°-183° C. were obtained.

후처리

  1. customthe ethanol was removed by distillation
  2. extractionthe aqueous phase was extracted twice with 10 ml of toluene
  3. filtrationThe precipitate was filtered off under suction
  4. washwashed with a little water
  5. customdried

출처 및 근거

ORD 기록
ord-f3576e277ae6453ba71ef2be29dddc90
출처 데이터셋
uspto-grants-1992_01
특허 번호
US05082949

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