Acetic Anhydride → 3-[1-(Acetamido)tridecyl]-5-trimethylsilylfuran

HRID 1090895노트

반응식

HRID 1090895 반응식
[C:1](OC(=O)C)(=[O:3])[CH3:2].[NH2:8][CH:9]([C:22]1[CH:26]=[C:25]([Si:27]([CH3:30])([CH3:29])[CH3:28])[O:24][CH:23]=1)[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21].C(N(CC)CC)C>ClCCl>[C:1]([NH:8][CH:9]([C:22]1[CH:26]=[C:25]([Si:27]([CH3:30])([CH3:29])[CH3:28])[O:24][CH:23]=1)[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])(=[O:3])[CH3:2]

참가 물질

5

반응물 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 150370773-(1-Aminotridecyl)-5-trimethylsilylfuran

생성물 1

HCID 150370783-[1-(Acetamido)tridecyl]-5-trimethylsilylfuran

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Acetic anhydride (0.1 ml) was added to a solution of 3-(1-aminotridecyl)-5-trimethylsilylfuran (89.8 mg, 0.27 mmol) and triethylamine (0.1 ml) in dichloromethane (1 ml) at room temperature. Stirring was continued overnight (14 hours) while the cooling bath attained room temperature. The residue, after solvent removal, was purified by preparative TLC (20×20 cm, 1000u; developed with 60% ethyl ether/hexane). The title amid was obtained as a pale yellow oil.

후처리

  1. custom(14 hours)
  2. customwhile the cooling bath attained room temperature
  3. customThe residue, after solvent removal
  4. customwas purified by preparative TLC (20×20 cm, 1000u; developed with 60% ethyl ether/hexane)
  5. customThe title amid was obtained as a pale yellow oil

출처 및 근거

ORD 기록
ord-a6687f0f2b054e17a62fab25756fb28a
출처 데이터셋
uspto-grants-1992_01
특허 번호
US05082954

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