Sodium hydride → Ethyl 6,12-dithiatetradecanoate

HRID 1090935노트

반응식

[CH2:1]([S:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][SH:9])[CH3:2].[H-].[Na+].I[CH2:13][CH2:14][CH2:15][CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18]>>[C:17]([O:19][CH2:20][CH3:21])(=[O:18])[CH2:16][CH2:15][CH2:14][CH2:13][S:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][S:3][CH2:1][CH3:2]

참가 물질

반응물 3

HCID 24758Sodium hydride

HCID 4169827Ethyl 5-iodopentanoate

HCID 234238685-Ethylthiopentanethiol

생성물 1

HCID 15020143Ethyl 6,12-dithiatetradecanoate

실험 절차

To illustrate the preparation of the dithia-substituted fatty acid ethers, 5-ethylthiopentane thiol can be reacted with sodium hydride and the resulting product reacted with ethyl 5-iodovalerate to yield ethyl 6,12-dithiatetradecanoate. The ester group can then be removed by treatment with alkali metal hydroxide, e.g. NaOH, to produce the desired 6,12-dithiatetradecanoic acid.

출처 및 근거

ORD 기록: ord-1bf3098c22db4fb58e71d4fdebd78d6b
출처 데이터셋: uspto-grants-1992_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05082967

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