HCID 15611138, 화합물 → HCID 53859730, 화합물

HRID 1091131노트

반응식

HRID 1091131 반응식
[O:1]1[CH2:3][CH:2]1[CH2:4][O:5][C:6]1[CH:23]=[CH:22][CH:21]=[CH:20][C:7]=1[C:8]([NH:10][C:11]1[CH:19]=[CH:18][CH:17]=[C:16]2[C:12]=1[CH:13]=[CH:14][NH:15]2)=[O:9]>C(O)C.C(N)CC>[OH:1][CH:2]([CH2:3][NH:10][CH2:8][CH2:7][CH3:6])[CH2:4][O:5][C:6]1[CH:23]=[CH:22][CH:21]=[CH:20][C:7]=1[C:8]([NH:10][C:11]1[CH:19]=[CH:18][CH:17]=[C:16]2[C:12]=1[CH:13]=[CH:14][NH:15]2)=[O:9]

참가 물질

4

반응물 1

HCID 15611138HCID 15611138, 화합물

생성물 1

HCID 53859730HCID 53859730, 화합물수율 151.6%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 7852Propylamine용매

실험 절차

3.1 g of 2-[(2-oxiranyl) methoxy]-N-(1H-indol-4-yl) benzamide prepared as in example 4 is heated for 2 hours to reflux in 60 cm3 of ethanol and 8.5 cm3 of n-propylamine. The solvents are eliminated under reduced pressure at 50° C., the residue is chromatographed on silica (eluent: chloroform-methanol 7-3) to obtain 2.8 g of 2-[2-hydroxy-3-(propylamino)-propoxy]-N-(1H-indol-4-yl) benzamide.

후처리

  1. temperatureis heated for 2 hours
  2. customare eliminated under reduced pressure at 50° C.
  3. customthe residue is chromatographed on silica (eluent: chloroform-methanol 7-3)

출처 및 근거

ORD 기록
ord-2bcbe5c7f5084186a3bb191fe040e064
출처 데이터셋
uspto-grants-1992_01
특허 번호
US05084455

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