Acetyl chloride → 2'-Iodoacetanilide

HRID 1092412노트

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HRID 1092412 반응식
[I:1][C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[NH2:4].[C:9](Cl)(=[O:11])[CH3:10]>N1C=CC=CC=1.Cl>[I:1][C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[NH:4][C:9](=[O:11])[CH3:10]

참가 물질

5

반응물 2

HCID 6367Acetyl chlorideHCID 119952-Iodoaniline

생성물 1

HCID 1405592'-Iodoacetanilide

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 1049Pyridine용매

반응 조건

온도
0 °C

실험 절차

2-Iodoaniline (1.00 g, 4.56 mmol) was dissolved in pyridine (5 mL) and cooled to 0° C. After acetyl chloride (314 μL, 5.94 mmol) was added, the reaction was stirred at 0° C. for 1 hour and then at room temperature for 2 hours. The reaction was diluted with 1 N HCl and extracted with ether. The organic layer was dried (MgSO4) and concentrated to give the desired acetamide (assumed quantitative), which was used in the next reaction without further purification.

후처리

  1. waitat room temperature for 2 hours
  2. extractionextracted with ether
  3. dry with materialThe organic layer was dried (MgSO4)
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-57a8314e94374a3bac43794109d4db44
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08129424B2

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