Hydrochloric Acid → HCID 178526855, 화합물

HRID 1092883노트

반응식

HRID 1092883 반응식
F[B-](F)(F)F.[O:6]=[N+:7]=[O:8].[Cl:9][C:10]1[NH:11][CH:12]=[CH:13][N:14]=1.C(=O)([O-])O.[Na+].Cl>[N+](C)([O-])=O>[Cl:9][C:10]1[NH:11][CH:12]=[C:13]([N+:7]([O-:8])=[O:6])[N:14]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 27733282-chloro-1H-imidazoleHCID 11073463Nitronium tetrafluoroborate

생성물 1

HCID 178526855HCID 178526855, 화합물수율 34.9%

시약·촉매·용매 1

HCID 6375Nitromethane용매

실험 절차

Nitronium tetrafluoroborate (398 mg) was dissolved in nitromethane (5 ml), next 2-chloroimidazole (205 mg) was added, the reaction mixture was stirred at a room temperature for 1 hour. The reaction mixture was neutralized with an aqueous solution of sodium hydrogencarbonate, then was turned back to acidic by adding hydrochloric acid, the separated 2-chloro-4-nitroimidazole (137 mg) was collected by filtration. The filtrate was extracted with ethyl acetate-methanol, the solid matter obtained from the organic layer was triturated with diethyl ether, 2-chloro-4-nitroimidazole (103 mg) was obtained. The sum of 240 mg (yield: 81.3%) of 2-chloro-4-nitroimidazole was obtained as colorless solid product.

후처리

  1. filtrationthe separated 2-chloro-4-nitroimidazole (137 mg) was collected by filtration
  2. extractionThe filtrate was extracted with ethyl acetate-methanol
  3. customthe solid matter obtained from the organic layer
  4. customwas triturated with diethyl ether

출처 및 근거

ORD 기록
ord-ce1bc40b01ae461da076c59eefa182fd
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08129544B2

반응 노트

불러오는 중…