Thiourea → 4-Methyl-5-(3-nitro-phenyl)-thiazol-2-ylamine

HRID 1092983노트

반응식

HRID 1092983 반응식
Br[CH:2]([C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([N+:12]([O-:14])=[O:13])[CH:7]=1)[C:3](=O)[CH3:4].[NH2:15][C:16]([NH2:18])=[S:17]>C(O)C>[CH3:4][C:3]1[N:15]=[C:16]([NH2:18])[S:17][C:2]=1[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([N+:12]([O-:14])=[O:13])[CH:7]=1

참가 물질

4

반응물 2

HCID 2723790ThioureaHCID 85861734HCID 85861734, 화합물

생성물 1

HCID 183229114-Methyl-5-(3-nitro-phenyl)-thiazol-2-ylamine

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
70 °C

실험 절차

A stirred solution of 1-Bromo-1-(3-nitro-phenyl)-propan-2-one (98a) (2.4 g, 9.3 mmol) in ethanol (20 ml) at room temperature is treated with thiourea (0.71 g, 9.3 mmol). The reaction mixture is heated to 70° C. for 10 minutes. The resulting precipitate is removed by filtration and dried under vacuum to give the titled compound.

후처리

  1. customThe resulting precipitate is removed by filtration
  2. customdried under vacuum

출처 및 근거

ORD 기록
ord-1c6cbfdd0fcc4e728c8e78f5648bef0b
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08129541B2

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