Thiourea → 5-(3-Methanesulphonyl-phenyl)-4-methyl-thiazol-2-ylamine hydrobromide

HRID 1093016노트

반응식

HRID 1093016 반응식
[Br:1][CH:2]([C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([S:12]([CH3:15])(=[O:14])=[O:13])[CH:7]=1)[C:3](=O)[CH3:4].[NH2:16][C:17]([NH2:19])=[S:18]>>[BrH:1].[CH3:15][S:12]([C:8]1[CH:7]=[C:6]([C:2]2[S:18][C:17]([NH2:19])=[N:16][C:3]=2[CH3:4])[CH:11]=[CH:10][CH:9]=1)(=[O:14])=[O:13]

참가 물질

3

반응물 2

HCID 2723790ThioureaHCID 858616531-Bromo-1-(3-methanesulphonyl-phenyl)-propanone

생성물 1

HCID 865984455-(3-Methanesulphonyl-phenyl)-4-methyl-thiazol-2-ylamine hydrobromide

실험 절차

A stirred solution of 1-bromo-1-(3-methanesulphonyl-phenyl)-propanone (176c) (0.32 g, 1.01 mmol) is treated with thiourea (0.067 g, 0.88 mmol) added in one portion. The reaction mixture is allowed to stir at room temperature over two days. The product precipitates out and is filtered to yield the tittle compound as while solid.

후처리

  1. additionadded in one portion
  2. customThe product precipitates out
  3. filtrationis filtered
  4. customto yield the tittle compound as while solid

출처 및 근거

ORD 기록
ord-efcd0b8db4c141daa6ce6ce7087f38f3
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08129541B2

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