Hydrochloric Acid → Ethyl 10-(ethylamino)-4-oxo-3-((phenylcarbonyl)oxy)-4,6,7,8,9,10-hexahydro-7,10-ethanopyrimido[1,2-a]azepine-2-carboxylate

HRID 1093085노트

반응식

HRID 1093085 반응식
[CH2:1]([N:8](CC)[C:9]12[CH2:17][CH2:16][CH:13]([CH2:14][CH2:15]1)[CH2:12][N:11]1[C:18](=[O:36])[C:19]([O:27][C:28]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)=[O:29])=[C:20]([C:22]([O:24][CH2:25][CH3:26])=[O:23])[N:21]=[C:10]21)[C:2]1C=CC=CC=1.Cl.[H][H]>CO.[Pd]>[CH2:1]([NH:8][C:9]12[CH2:17][CH2:16][CH:13]([CH2:14][CH2:15]1)[CH2:12][N:11]1[C:18](=[O:36])[C:19]([O:27][C:28]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)=[O:29])=[C:20]([C:22]([O:24][CH2:25][CH3:26])=[O:23])[N:21]=[C:10]21)[CH3:2]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 57905266Ethyl 10-(benzyl(ethyl)amino)-4-oxo-3-((phenylcarbonyl)oxy)-4,6,7,8,9,10-hexahydro-7,10-ethanopyrimido[1,2-a]azepine-2-carboxylateHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 57904946Ethyl 10-(ethylamino)-4-oxo-3-((phenylcarbonyl)oxy)-4,6,7,8,9,10-hexahydro-7,10-ethanopyrimido[1,2-a]azepine-2-carboxylate

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a mixture of ethyl 10-(benzyl(ethyl)amino)-4-oxo-3-((phenylcarbonyl)oxy)-4,6,7,8,9,10-hexahydro-7,10-ethanopyrimido[1,2-a]azepine-2-carboxylate (120 mg, 0.233 mmol) in methanol (5 mL) was added 1N HCl (0.256 mL, 0.256 mmol) followed by Pd/C (24.77 mg, 0.023 mmol) and the mixture stirred under 1 atm hydrogen for 18 h. The mixture was filtered and the solids thoroughly washed with dichloromethane. The filtrate was concentrated under reduced pressure and dried under high vacuum overnight to afford the title compound.

후처리

  1. filtrationThe mixture was filtered
  2. washthe solids thoroughly washed with dichloromethane
  3. concentrationThe filtrate was concentrated under reduced pressure
  4. customdried under high vacuum overnight

출처 및 근거

ORD 기록
ord-f11a9c1fdb3d4a3e95dd4450e8cbde49
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08129398B2

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