Benzoyl Peroxide → 1-Bromo-3-(bromomethyl)-2-chloro-4-fluorobenzene

HRID 1093917노트

반응식

HRID 1093917 반응식
[Br:1][C:2]1[C:3]([Cl:10])=[C:4]([CH3:9])[C:5]([F:8])=[CH:6][CH:7]=1.[Br:11]N1C(=O)CCC1=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[C:4]([CH2:9][Br:11])[C:3]=1[Cl:10]

참가 물질

5

반응물 3

HCID 7187Benzoyl PeroxideHCID 67184N-bromobutanimideHCID 27362271-Bromo-2-chloro-4-fluoro-3-methylbenzene

생성물 1

HCID 579988441-Bromo-3-(bromomethyl)-2-chloro-4-fluorobenzene수율 98.9%

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

실험 절차

3-Bromo-2-chloro-6-fluoro-toluene (8.0 g), N-bromosuccinimide (NBS) (6.42 g) and a catalytic amount of benzoyl peroxide in carbon tetrachloride (40 ml) were heated to reflux. A 500 watt tungsten halogen lamp was used to initiate the reaction. The reaction mixture was heated to reflux and irradiated for 30 minutes. The reaction mixture was allowed to cool and then filtered. The filtrate was concentrated to give a colourless oil which solidified on standing to give 1-bromo-3-bromomethyl-2-chloro-4-fluorobenzene as an off-white solid (10.7 g).

후처리

  1. customthe reaction
  2. temperatureThe reaction mixture was heated
  3. temperatureto reflux
  4. customirradiated for 30 minutes
  5. temperatureto cool
  6. filtrationfiltered
  7. concentrationThe filtrate was concentrated
  8. customto give a colourless oil which

출처 및 근거

ORD 기록
ord-bb0dccba06ac4f86b58be026ade3954f
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08133847B2

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