Hydroxyamine hydrochloride → HCID 86633070, 화합물

HRID 1094216노트

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HRID 1094216 반응식
[CH:1]1([NH:7][C:8]2[CH:17]=[C:16]3[C:11]([C:12](=[O:25])[C:13]([CH:23]=O)=[CH:14][N:15]3[CH:18]3[CH2:22][CH2:21][CH2:20][CH2:19]3)=[CH:10][C:9]=2[F:26])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C([O-])(=O)C.[Na+].Cl.[NH2:33][OH:34]>C(O)C>[CH:1]1([NH:7][C:8]2[CH:17]=[C:16]3[C:11]([C:12](=[O:25])[C:13]([CH:23]=[N:33][OH:34])=[CH:14][N:15]3[CH:18]3[CH2:22][CH2:21][CH2:20][CH2:19]3)=[CH:10][C:9]=2[F:26])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

5

반응물 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 866330517-(Cyclohexylamino)-1-cyclopentyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carbaldehyde

생성물 1

HCID 86633070HCID 86633070, 화합물수율 57.6%

시약·촉매·용매 1

HCID 702Ethanol용매

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온도
70 °C

실험 절차

To 500 mg of 7-(cyclohexylamino)-1-cyclopentyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carbaldehyde were added 5 ml of ethanol, 460 mg of sodium acetate and 290 mg of hydroxylamine hydrochloride, followed by stirring at room temperature for 15 hours and at 70° C. for 12 hours. The solvent was evaporated under a reduced pressure, and water was added to the resulting residue, followed by extraction with chloroform and washing with aqueous saturated sodium chloride. After drying over anhydrous sodium sulfate, the solvent was evaporated under a reduced pressure to obtain 300 mg of 7-(cyclohexylamino)-1-cyclopentyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carbaldehyde oxime.

후처리

  1. customThe solvent was evaporated under a reduced pressure, and water
  2. additionwas added to the resulting residue
  3. extractionfollowed by extraction with chloroform
  4. washwashing with aqueous saturated sodium chloride
  5. dry with materialAfter drying over anhydrous sodium sulfate
  6. customthe solvent was evaporated under a reduced pressure

출처 및 근거

ORD 기록
ord-1f20ca60c9ca4c1aaa5bb724f5db6829
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08133882B2

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