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Diisopropylethylamine → 4-allyloxy-3,5-dimethyl-benzoic acid N'-(5-isobutyl-thiophene-2-carbonyl)-hydrazide

HRID 1094304
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HRID 1094304 반응식
[CH2:1]([C:5]1[S:9][C:8]([C:10]([OH:12])=O)=[CH:7][CH:6]=1)[CH:2]([CH3:4])[CH3:3].CCN(C(C)C)C(C)C.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.[CH2:44]([O:47][C:48]1[C:57]([CH3:58])=[CH:56][C:51]([C:52]([NH:54][NH2:55])=[O:53])=[CH:50][C:49]=1[CH3:59])[CH:45]=[CH2:46]>C(Cl)Cl.CCOCC>[CH2:1]([C:5]1[S:9][C:8]([C:10]([NH:55][NH:54][C:52](=[O:53])[C:51]2[CH:50]=[C:49]([CH3:59])[C:48]([O:47][CH2:44][CH:45]=[CH2:46])=[C:57]([CH3:58])[CH:56]=2)=[O:12])=[CH:7][CH:6]=1)[CH:2]([CH3:3])[CH3:4]
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참가 물질

7

반응물 4

HCID 81531DiisopropylethylamineHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 196226895-(2-Methylpropyl)thiophene-2-carboxylic acidHCID 592020394-Allyloxy-3,5-dimethyl-benzoic acid hydrazide

생성물 1

HCID 666369514-allyloxy-3,5-dimethyl-benzoic acid N'-(5-isobutyl-thiophene-2-carbonyl)-hydrazide수율 80.5%

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 6344Dichloromethane용매

실험 절차

To a solution of 5-isobutyl-thiophene-2-carboxylic acid (830 mg, 4.51 mmol) and DIPEA (680 mg, 5.27 mmol) in DCM (20 mL) is added TBTU (1.59 g, 4.96 mmol) at rt. The mixture is stirred at rt for 45 min before 4-allyloxy-3,5-dimethyl-benzoic acid hydrazide (993 mg, 4.50 mmol) is added. Stirring is continued for 2 h. The mixture is diluted with ether (200 mL) and washed with 1M aq. HCl (3×50 mL), 1M aq. NaOH (3×50 mL) and brine (50 mL). The org. extract is dried over MgSO4, filtered and evaporated to give the crude 4-allyloxy-3,5-dimethyl-benzoic acid N′-(5-isobutyl-thiophene-2-carbonyl)-hydrazide (1.40 g) as a yellow oil that slowly solidifies; LC-MS: tR=1.02 min, [M+1]+=387.10.

후처리

  1. additionis added
  2. washwashed with 1M aq. HCl (3×50 mL), 1M aq. NaOH (3×50 mL) and brine (50 mL)
  3. extractionextract
  4. dry with materialis dried over MgSO4
  5. filtrationfiltered
  6. customevaporated

출처 및 근거

ORD 기록
ord-4257db04a7554dfa812ac90998635693
출처 데이터셋
uspto-grants-2012_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08133910B2

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