Hydrochloric Acid → (S)-2-Amino-N-(3,4-dimethyl-phenyl)-N-[2-(5-methyl-pyridin-2-yl)-ethyl]-2-phenyl-acetamide dihydrochloride

HRID 1094360노트

반응식

HRID 1094360 반응식
C(OC(=O)[NH:7][C@H:8]([C:15](=[O:34])[N:16]([C:26]1[CH:31]=[CH:30][C:29]([CH3:32])=[C:28]([CH3:33])[CH:27]=1)[CH2:17][CH2:18][C:19]1[CH:24]=[CH:23][C:22]([CH3:25])=[CH:21][N:20]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)(C)(C)C.[ClH:36]>O1CCOCC1>[ClH:36].[ClH:36].[NH2:7][C@@H:8]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:15]([N:16]([C:26]1[CH:31]=[CH:30][C:29]([CH3:32])=[C:28]([CH3:33])[CH:27]=1)[CH2:17][CH2:18][C:19]1[CH:24]=[CH:23][C:22]([CH3:25])=[CH:21][N:20]=1)=[O:34]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 58007500((S)-{(3,4-dimethyl-phenyl)-[2-(5-methyl-pyridin-2-yl)-ethyl]-carbamoyl}-phenyl-methyl)-carbamic acid tert-butyl ester

생성물 1

HCID 66638324(S)-2-Amino-N-(3,4-dimethyl-phenyl)-N-[2-(5-methyl-pyridin-2-yl)-ethyl]-2-phenyl-acetamide dihydrochloride수율 94%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매2회

실험 절차

To a solution of 50 mg (0.11 mmol) ((S)-{(3,4-dimethyl-phenyl)-[2-(5-methyl-pyridin-2-yl)-ethyl]-carbamoyl}-phenyl-methyl)-carbamic acid tert-butyl ester in 0.2 mL dioxane was added 265 uL (1.06 mmol) of a 4 M HCl solution in dioxane. The mixture was stirred at room temperature for 18 hours. The solvent was removed in vacuo. Ethylacetate was added and the mixture was stirred slowly at ambient temperature. The solid was filtered, rinsed with ether and dried under vacum to provide 0.044 g (94%) of the title compound as a light yellow solid MS (m/e): 374.3 [M+H]+.

후처리

  1. customThe solvent was removed in vacuo
  2. additionEthylacetate was added
  3. stirringthe mixture was stirred slowly at ambient temperature
  4. filtrationThe solid was filtered
  5. washrinsed with ether
  6. customdried under vacum

출처 및 근거

ORD 기록
ord-5cca32afd15f4b7782340662653add78
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08133909B2

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