5,6,7,8-Tetrahydro-2-naphthylamine → (S)-2-(4-Fluoro-phenyl)-2-hydroxy-N-(5,6,7,8-tetrahydro-naphthalen-2-yl)-N-[2-(6-trifluoromethyl-pyridin-3-yl)-ethyl]-acetamide

HRID 1094409

반응식

HRID 1094409 반응식
[CH:1]1[C:10]2[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=2[CH:4]=[CH:3][C:2]=1[NH2:11].[F:12][C:13]([F:24])([F:23])[C:14]1[N:19]=[CH:18][C:17]([CH2:20][C:21]#N)=[CH:16][CH:15]=1.[F:25][C:26]1[CH:31]=[CH:30][C:29]([C:32](=[O:36])[C:33](O)=[O:34])=[CH:28][CH:27]=1>>[F:25][C:26]1[CH:27]=[CH:28][C:29]([C@H:32]([OH:36])[C:33]([N:11]([C:2]2[CH:3]=[CH:4][C:5]3[CH2:6][CH2:7][CH2:8][CH2:9][C:10]=3[CH:1]=2)[CH2:21][CH2:20][C:17]2[CH:18]=[N:19][C:14]([C:13]([F:24])([F:23])[F:12])=[CH:15][CH:16]=2)=[O:34])=[CH:30][CH:31]=1

참가 물질

4

반응물 3

HCID 751935,6,7,8-Tetrahydro-2-naphthylamineHCID 5794402-(4-Fluorophenyl)-2-oxoacetic AcidHCID 508511273-Pyridineacetonitrile, 6-(trifluoromethyl)-

생성물 1

HCID 44546438(S)-2-(4-Fluoro-phenyl)-2-hydroxy-N-(5,6,7,8-tetrahydro-naphthalen-2-yl)-N-[2-(6-trifluoromethyl-pyridin-3-yl)-ethyl]-acetamide

실험 절차

In analogy to example 47 (steps 3 & 4), 5,6,7,8-Tetrahydro-naphthalen-2-ylamine, (6-Trifluoromethyl-pyridin-3-yl)-acetonitrile & (4-Fluoro-phenyl)-oxo-acetic acid were successively coupled then reduced to give after chiral chromatography (+ve rotation) the target compound. MS(m/e): 473.1 [M+H]+.

후처리

  1. customto give after chiral chromatography (+ve rotation) the target compound

출처 및 근거

ORD 기록
ord-e3eca01a8f8a4393a9294845399bf821
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08133909B2

연결된 노트

불러오는 중…