Ethyl 3-{[(3'-{[(2-aminoanilino)carbothioyl]amino}[1,1'-biphenyl]-3-yl)sulfonyl]amino}-3-phenyl-propanoate → Ethyl 3-{[3'-(1H-benzimidazol-2-ylamino)[1,1'-biphenyl]3-yl]-sulfonylamino}-3-phenyl-propanoate

HRID 10947

반응식

HRID 10947 반응식
[NH2:1][C:2]1[CH:40]=[CH:39][CH:38]=[CH:37][C:3]=1[NH:4][C:5]([NH:7][C:8]1[CH:9]=[C:10]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([S:20]([NH:23][CH:24]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)[CH2:25][C:26]([O:28][CH2:29][CH3:30])=[O:27])(=[O:22])=[O:21])[CH:15]=2)[CH:11]=[CH:12][CH:13]=1)=S>[Hg]=O.C(Cl)(Cl)Cl>[NH:4]1[C:3]2[CH:37]=[CH:38][CH:39]=[CH:40][C:2]=2[N:1]=[C:5]1[NH:7][C:8]1[CH:9]=[C:10]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([S:20]([NH:23][CH:24]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)[CH2:25][C:26]([O:28][CH2:29][CH3:30])=[O:27])(=[O:22])=[O:21])[CH:15]=2)[CH:11]=[CH:12][CH:13]=1

참가 물질

4

반응물 1

HCID 21982385Ethyl 3-{[(3'-{[(2-aminoanilino)carbothioyl]amino}[1,1'-biphenyl]-3-yl)sulfonyl]amino}-3-phenyl-propanoate

생성물 1

HCID 21982519Ethyl 3-{[3'-(1H-benzimidazol-2-ylamino)[1,1'-biphenyl]3-yl]-sulfonylamino}-3-phenyl-propanoate

시약·촉매·용매 2

HCID 30856Mercuric oxide촉매HCID 6212Chloroform용매

실험 절차

43 g (75 mmol) of Ethyl 3-{[(3′-{[(2-aminoanilino)carbothioyl]amino}[1,1′-biphenyl]-3-yl)sulfonyl]amino}-3-phenyl-propanoate 11.1.1 and 16.24 g (75 mmol) of yellow mercury oxide were mixed with 1.51 CHCl3 and refluxed for 6 h. The resulting material was purified via flash chromatography (dichloromethane/acetic acid ethyl ester 3+1). Recrystallization from acetic acid ethyl ester led to 27.8 g (68%).

후처리

  1. temperaturerefluxed for 6 h
  2. customThe resulting material was purified via flash chromatography (dichloromethane/acetic acid ethyl ester 3+1)
  3. customRecrystallization from acetic acid ethyl ester

출처 및 근거

ORD 기록
ord-660d63e58a12491cb152bc9a8923af2b
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07094911B2

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