Acetic Acid → 5-(Methoxymethyl)isoxazole-4-carboxylic acid
반응식
[CH3:1][O:2][CH2:3][C:4]1[O:8][N:7]=[CH:6][C:5]=1[C:9]([O:11]C)=[O:10].Cl.C(O)(=O)C.O>CC(C)=O>[CH3:1][O:2][CH2:3][C:4]1[O:8][N:7]=[CH:6][C:5]=1[C:9]([OH:11])=[O:10]참가 물질
6
실험 절차
Methyl 5-(methoxymethyl)isoxazole-4-carboxylate (Preparation 42, 1.8 g, 11 mmol) was stirred in a 1:1:1 mixture of concentrated hydrochloric acid (2 ml), acetic acid (2 ml) and water (2 ml) at reflux for 6 hours. Acetone (6 ml) was added and the mixture concentrated in vacuo. The solid residue was triturated with ethyl acetate and the filtrate concentrated in vacuo to afford the title compound as an off white solid (1.4 g, 85% yield).
후처리
- temperatureat reflux for 6 hours
- concentrationthe mixture concentrated in vacuo
- customThe solid residue was triturated with ethyl acetate
- concentrationthe filtrate concentrated in vacuo
출처 및 근거
- ORD 기록
- ord-ba0c447e30bf4982a99d930cff454302
- 출처 데이터셋
- uspto-grants-2012_03
- 특허 번호
- US08134007B2
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