Iodoethane → 2-Bromo-4-ethoxy-1-(trifluoromethoxy)benzene

HRID 1094821노트

반응식

HRID 1094821 반응식
[Br:1][C:2]1[CH:3]=[C:4]([OH:13])[CH:5]=[CH:6][C:7]=1[O:8][C:9]([F:12])([F:11])[F:10].[CH2:14](I)[CH3:15].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[Br:1][C:2]1[CH:3]=[C:4]([O:13][CH2:14][CH3:15])[CH:5]=[CH:6][C:7]=1[O:8][C:9]([F:11])([F:12])[F:10]

참가 물질

5

반응물 3

HCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 27571943-Bromo-4-(trifluoromethoxy)phenol

생성물 1

HCID 575823322-Bromo-4-ethoxy-1-(trifluoromethoxy)benzene수율 125%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To a solution of the 3-bromo-4-trifluoromethoxyphenol (1.0 g, 2.48 mmol) in acetone (30 ml) was added ethyl iodide (0.795 ml, 9.94 mmol) followed by potassium carbonate (1.37 g, 9.94 mmol) and the reaction was heated to reflux for 12 hrs. The reaction mixture was cooled then filtered and concentrated in vacuo. Dichloromethane (20 ml) and water (20 ml) were added and the solution was filtered through a phase separation cartridge. The organic layer was collected, and evaporated in vacuo to afford crude title compound as a colourless oil (884 mg, 80%). Material was taken on without further purification.

후처리

  1. temperaturethe reaction was heated
  2. temperatureto reflux for 12 hrs
  3. temperatureThe reaction mixture was cooled
  4. filtrationthen filtered
  5. concentrationconcentrated in vacuo
  6. additionDichloromethane (20 ml) and water (20 ml) were added
  7. filtrationthe solution was filtered through a phase separation cartridge
  8. customThe organic layer was collected
  9. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-20340259bcdd4fb399ce84fc14ed2e5a
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08134007B2

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