Pyrrolidine → (3-Bromobenzoyl)pyrrolidine
반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5](Cl)=[O:6].[NH:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1>C(Cl)Cl>[Br:1][C:2]1[CH:3]=[C:4]([C:5]([N:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)=[O:6])[CH:8]=[CH:9][CH:10]=1참가 물질
4
실험 절차
A solution of 3-bromo-benzoyl chloride (2.7 g, 12 mmol) in DCM (40 mL) was chilled to zero degrees and treated with pyrrolidine (3 mL, 36.8 mmol). Reaction was allowed to come to room temperature and stir for 4 h. Mixture was then poured onto water and washed once. Organic phase then washed with brine, dried over sodium sulfate, filtered and evaporated to amber oil (3.1 g, 100%).
후처리
- customReaction
- customto come to room temperature
- additionMixture was then poured onto water
- washwashed once
- washOrganic phase then washed with brine
- dry with materialdried over sodium sulfate
- filtrationfiltered
- customevaporated to amber oil (3.1 g, 100%)
출처 및 근거
- ORD 기록
- ord-4fba56b3143740a9a365abd569e476c4
- 출처 데이터셋
- uspto-grants-2012_03
- 특허 번호
- US08133900B2
반응 노트
불러오는 중…