Chloroform → (4-chloro-2-phenyl-2H-pyrazolo[3,4-c]quinolin-1-yl)acetyl chloride

HRID 1095364노트

반응식

HRID 1095364 반응식
O=[C:2]1[C:11]2=[N:12][N:13]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:14](CC(O)=O)=[C:10]2[C:9]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=2[NH:3]1.[C:25](Cl)(=O)[C:26]([Cl:28])=[O:27].C(Cl)(Cl)[Cl:32]>CN(C=O)C>[Cl:32][C:2]1[C:11]2=[N:12][N:13]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:14]([CH2:25][C:26]([Cl:28])=[O:27])=[C:10]2[C:9]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=2[N:3]=1

참가 물질

5

반응물 3

HCID 6212ChloroformHCID 65578Oxalyl chlorideHCID 57446227HCID 57446227, 화합물

생성물 1

HCID 57446229(4-chloro-2-phenyl-2H-pyrazolo[3,4-c]quinolin-1-yl)acetyl chloride

시약·촉매·용매 1

HCID 6228Dimethylformamide촉매

실험 절차

(4-Oxo-2-phenyl-4,5-dihydro-2H-pyrazolo[3,4-c]quinolin-1-yl)acetic acid (8.83 g, 27.7 mmol) was suspended in 175 mL of chloroform. Twenty drops of DMF were added followed by oxalyl chloride (7.2 mL, 83.0 mmol). The reaction mixture was stirred at ambient temperature for 1 hour and concentrated under reduced pressure at 40° C. to afford crude (4-chloro-2-phenyl-2H-pyrazolo[3,4-c]quinolin-1-yl)acetyl chloride.

후처리

  1. concentrationconcentrated under reduced pressure at 40° C.

출처 및 근거

ORD 기록
ord-c565a5dbc7444008a13ab7c0be721eab
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08138173B2

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