Tryptamine → N-Acetyltryptamine

HRID 1095501노트

반응식

HRID 1095501 반응식
[NH2:1][CH2:2][CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[NH:6][CH:5]=1.C(N(CC)CC)C.[C:20](OC(=O)C)(=[O:22])[CH3:21]>C1COCC1>[NH:6]1[C:7]2[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:4]([CH2:3][CH2:2][NH:1][C:20](=[O:22])[CH3:21])=[CH:5]1

참가 물질

5

반응물 3

HCID 1150TryptamineHCID 7918Acetic AnhydrideHCID 8471Triethylamine

생성물 1

HCID 70547N-Acetyltryptamine

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Tryptamine (192 mg/1.2 mmol) was initially introduced into abs. THF (5 ml), and triethylamine (179 μl/1.3 mmol) was added. Acetic anhydride (132 mg/1.3 mmol) was then added and the mixture was stirred at RT for 4 h. The mixture was concentrated to dryness i. vac. The residue was taken up in ethyl acetate and this solution was washed with saturated NaHCO3 solution (two times 20 ml) and with NaCl solution (two times 20 ml). The organic phase was dried over Na2SO4 and concentrated i. vac.

후처리

  1. concentrationThe mixture was concentrated to dryness i
  2. washthis solution was washed with saturated NaHCO3 solution (two times 20 ml) and with NaCl solution (two times 20 ml)
  3. dry with materialThe organic phase was dried over Na2SO4
  4. concentrationconcentrated i

출처 및 근거

ORD 기록
ord-2ce0a80823754975b947e0a7fceb9774
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08138187B2

반응 노트

불러오는 중…