Phosphorus oxybromide → 2,8-Dibromoquinoline

HRID 1095668

반응식

HRID 1095668 반응식
[Br:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[NH:10][C:9](=O)[CH:8]=[CH:7]2.P(Br)(Br)([Br:15])=O>O>[Br:15][C:9]1[CH:8]=[CH:7][C:6]2[C:11](=[C:2]([Br:1])[CH:3]=[CH:4][CH:5]=2)[N:10]=1

참가 물질

4

반응물 2

HCID 24613Phosphorus oxybromideHCID 109330948-Bromo-1,2-dihydroquinolin-2-one

생성물 1

HCID 459259512,8-Dibromoquinoline수율 80%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
140 °C

실험 절차

A mixture of 8-bromoquinolin-2(1H)-one (5 g, 22 mmol) and phosphoryl tribromide (13 g, 45 mmol) was heated to 140° C. for three hours. The resulting mixture was poured onto 100 g of ice and 100 ml water. The mixture was stirred for 1 hour and the resulting solids were filtered to yield the title compound. (5.1 g, 80% yield) MS APCI (+) 286, 288, and 290 (M+1 of each isotope combination) detected.

후처리

  1. filtrationthe resulting solids were filtered

출처 및 근거

ORD 기록
ord-f295163c5eb74fd1b7e6855b6c336ce1
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08138181B2

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