Chloroacetaldehyde → 7-Ethylimidazo[1,2-a]pyridine

HRID 1095738

반응식

HRID 1095738 반응식
[CH2:1]([C:3]1[CH:8]=[CH:7][N:6]=[C:5]([NH2:9])[CH:4]=1)[CH3:2].Cl[CH2:11][CH:12]=O>CCO>[CH2:1]([C:3]1[CH:8]=[CH:7][N:6]2[CH:11]=[CH:12][N:9]=[C:5]2[CH:4]=1)[CH3:2]

참가 물질

4

반응물 2

HCID 33ChloroacetaldehydeHCID 1184254-Ethylpyridin-2-amine

생성물 1

HCID 181844637-Ethylimidazo[1,2-a]pyridine수율 98.6%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 4-ethylpyridin-2-amine (3.21 g, 8.19 mmol), and chloroacetaldehyde (50% aqueous solution, 2.6 ml, 10.5 mmol) in EtOH (10 ml) was refluxed vigorously for 12 hours. The reaction mixture was concentrated, and the residue was suspended in saturated aqueous sodium bicarbonate solution. The aqueous mixture was extracted with CH2Cl2 and EtOAc, and the combined organic extracts were dried over Na2SO4, filtered and concentrated to afford the desired product (1.18 g, 98% yield) as a viscous oil. MS APCI (+) m/z 147.2 (M+1) detected.

후처리

  1. temperaturewas refluxed vigorously for 12 hours
  2. concentrationThe reaction mixture was concentrated
  3. extractionThe aqueous mixture was extracted with CH2Cl2 and EtOAc
  4. dry with materialthe combined organic extracts were dried over Na2SO4
  5. filtrationfiltered
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-a14ef65495744592aceb2fbe75dcfb13
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08138181B2

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