Hydrochloric Acid → 6-(5-Oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)spiro[chroman-2,4'-piperidin]-4-one hydrochloride

HRID 1096928노트

반응식

HRID 1096928 반응식
[O:1]=[C:2]1[C:23]2[C:18](=[CH:19][CH:20]=[C:21]([C:24]3[NH:28][C:27](=[O:29])[O:26][N:25]=3)[CH:22]=2)[O:17][C:4]2([CH2:9][CH2:8][N:7](C(OC(C)(C)C)=O)[CH2:6][CH2:5]2)[CH2:3]1.[ClH:30]>O1CCOCC1>[ClH:30].[O:29]=[C:27]1[O:26][N:25]=[C:24]([C:21]2[CH:22]=[C:23]3[C:18](=[CH:19][CH:20]=2)[O:17][C:4]2([CH2:9][CH2:8][NH:7][CH2:6][CH2:5]2)[CH2:3][C:2]3=[O:1])[NH:28]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 136058068Tert-butyl 4-oxo-6-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)spiro[chroman-2,4'-piperidine]-1'-carboxylate

생성물 1

HCID 1363426496-(5-Oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)spiro[chroman-2,4'-piperidin]-4-one hydrochloride

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

A suspension of 437 mg of tert-butyl 4-oxo-6-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-spiro[chroman-2,4′-piperidine]-1′-carboxylate in 10 mL of 4N HCl in dioxane was stirred at rt for 1d, the resultant white solid was filtered, and washed with ether. The collected white solid was dried in vacuo at 50° C. to give the intended compound as a colorless solid.

후처리

  1. filtrationthe resultant white solid was filtered
  2. washwashed with ether
  3. customThe collected white solid was dried in vacuo at 50° C.

출처 및 근거

ORD 기록
ord-aa33bb97832a42bdb80b9581269fa3df
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08138197B2

반응 노트

불러오는 중…