Hydrochloric Acid → 6-(6-Oxo-1,6-dihydropyridin-3-yl)spiro[chroman-2,4'-piperidin]-4-one hydrochloride

HRID 1096930노트

반응식

HRID 1096930 반응식
C[O:2][C:3]1[N:8]=[CH:7][C:6]([C:9]2[CH:10]=[C:11]3[C:28](=[CH:29][CH:30]=2)[O:27][C:14]2([CH2:19][CH2:18][N:17](C(OC(C)(C)C)=O)[CH2:16][CH2:15]2)[CH2:13][C:12]3=[O:31])=[CH:5][CH:4]=1.[ClH:32]>>[ClH:32].[O:2]=[C:3]1[NH:8][CH:7]=[C:6]([C:9]2[CH:10]=[C:11]3[C:28](=[CH:29][CH:30]=2)[O:27][C:14]2([CH2:19][CH2:18][NH:17][CH2:16][CH2:15]2)[CH2:13][C:12]3=[O:31])[CH:5]=[CH:4]1

참가 물질

3

반응물 2

HCID 313Hydrochloric AcidHCID 57930941Tert-Butyl 6-[6-(methoxy)pyridin-3-yl]-4-oxo-spiro[chroman-2,4'-piperidine]-1'-carboxylate

생성물 1

HCID 667818066-(6-Oxo-1,6-dihydropyridin-3-yl)spiro[chroman-2,4'-piperidin]-4-one hydrochloride

실험 절차

Tert-Butyl 6-[6-(methoxy)pyridin-3-yl]-4-oxo-spiro[chroman-2,4′-piperidine]-1′-carboxylate (550 mg) was suspended in conc. HCl aq. (10 ml) and stirred at 100 deg. for 20 h. After removal of the solvent, the resulted solid was washed with MeOH and Et2O to obtain the intended compound as a colorless solid.

후처리

  1. customAfter removal of the solvent
  2. washthe resulted solid was washed with MeOH and Et2O

출처 및 근거

ORD 기록
ord-7afb32bd2310406d95e54586a7e82680
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08138197B2

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