Dimethylformamide → HCID 57930910, 화합물

HRID 1096940노트

반응식

HRID 1096940 반응식
C(=O)([O-])[O-].[K+].[K+].I[CH2:8][CH3:9].CN(C=O)C.[OH:15][C:16]1[CH:17]=[C:18]([CH:23]=[C:24]([O:26][S:27]([C:30]([F:33])([F:32])[F:31])(=[O:29])=[O:28])[CH:25]=1)[C:19]([O:21][CH3:22])=[O:20]>C(OCC)C>[CH2:8]([O:15][C:16]1[CH:17]=[C:18]([CH:23]=[C:24]([O:26][S:27]([C:30]([F:33])([F:31])[F:32])(=[O:29])=[O:28])[CH:25]=1)[C:19]([O:21][CH3:22])=[O:20])[CH3:9]

참가 물질

6

반응물 4

HCID 6228DimethylformamideHCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 86635508HCID 86635508, 화합물

생성물 1

HCID 57930910HCID 57930910, 화합물

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

With cooling with ice, potassium carbonate (152 mg, 1.10 mmol) and iodoethane (0.088 mL, 1.10 mmol) were added to a DMF solution (2.0 mL) of methyl 3-hydroxy-5-trifluoromethane-sulfonyloxybenzoate (300 mg, 1.00 mmol), and stirred at room temperature for 14 hours. The reaction mixture was diluted with diethyl ether (30 mL), then washed with water and aqueous saturated sodium chloride solution, dried with sodium sulfate, and concentrated under reduced pressure. The residue was purified through silica gel column chromatography to obtain the title compound as a colorless oil.

후처리

  1. washwashed with water and aqueous saturated sodium chloride solution
  2. dry with materialdried with sodium sulfate
  3. concentrationconcentrated under reduced pressure
  4. customThe residue was purified through silica gel column chromatography

출처 및 근거

ORD 기록
ord-5f2e9731d06c4ea488963e6708c78729
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08138197B2

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