Potassium Phosphate, Tribasic → Methyl 2,6-dimethoxybiphenyl-4-carboxylate

HRID 1096976노트

반응식

HRID 1096976 반응식
Br[C:2]1[C:11]([O:12][CH3:13])=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][C:3]=1[O:14][CH3:15].[C:16]1(B(O)O)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.[O-]P([O-])([O-])=O.[K+].[K+].[K+]>[N+](CCCC)(CCCC)(CCCC)CCCC.[Br-].C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2].CC#N>[CH3:15][O:14][C:3]1[CH:4]=[C:5]([C:6]([O:8][CH3:9])=[O:7])[CH:10]=[C:11]([O:12][CH3:13])[C:2]=1[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

참가 물질

7

반응물 3

HCID 62657Potassium Phosphate, TribasicHCID 66827Phenylboronic AcidHCID 117713Methyl 4-bromo-3,5-dimethoxybenzoate

생성물 1

HCID 57930909Methyl 2,6-dimethoxybiphenyl-4-carboxylate

시약·촉매·용매 3

HCID 74236Tetrabutylammonium Bromide촉매HCID 178418228Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+)촉매HCID 6342Acetonitrile용매

실험 절차

PdCl2(dppf) (14.8 g) was added to a CH3CN (900 mL) solution of methyl 4-bromo-3,5-dimethoxybenzoate (25.0 g), phenylboronic acid (22.2 g), Bu4NBr (5.86 g) and K3PO4 (77.2 g), and stirred under heat for 14 hours. This was filtered through Celite, and the filtrate was concentrated and purified through column chromatography to obtain the title compound as a colorless solid.

후처리

  1. temperatureunder heat for 14 hours
  2. filtrationThis was filtered through Celite
  3. concentrationthe filtrate was concentrated
  4. custompurified through column chromatography

출처 및 근거

ORD 기록
ord-d3f5b8e3929b4e0d9c1c794ccf02fcd9
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08138197B2

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