Ethanol → 3-Amino-5-phenylselenophene-2-carboxamide

HRID 1097221노트

반응식

HRID 1097221 반응식
[NH2:1][C:2]1[CH:6]=[C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[Se:4][C:3]=1[C:13]#[N:14].C([OH:17])C>[OH-].[Na+]>[NH2:1][C:2]1[CH:6]=[C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[Se:4][C:3]=1[C:13]([NH2:14])=[O:17]

참가 물질

4

반응물 2

HCID 702EthanolHCID 866468883-Amino-5-phenylselenophene-2-carbonitrile

생성물 1

HCID 866468873-Amino-5-phenylselenophene-2-carboxamide수율 67%

시약·촉매·용매 1

HCID 14798Sodium Hydroxide용매

실험 절차

To a suspension of 3-amino-5-phenylselenophene-2-carbonitrile (4.0 g) in aqueous sodium hydroxide solution (120 mL, 10%) was added ethanol (50 mL) and the mixture refluxed for 45 min. The mixture was allowed to rt and the crystals separated were filtered off, washed with cold water and dried to give the product as golden yellow color solid (2.8 g, 67%), mp 184-186° C. 1H NMR (400 MHz, CDCl3): δ 7.50-7.53 (2H, m, Ar—H), 7.36-7.38 (3H, m, Ar—H), 7.04 (1H, s, H-4), 5.84 (2H, br s, —CONH2), 5.12 (2H, br s, —NH2).

후처리

  1. temperaturethe mixture refluxed for 45 min
  2. customwas allowed to rt
  3. customthe crystals separated
  4. filtrationwere filtered off
  5. washwashed with cold water
  6. customdried

출처 및 근거

ORD 기록
ord-9cb451e22a274ff2879b31780753d8a2
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08143237B2

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